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KMID : 0363119930060020213
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Korean Journal of Pain
1993 Volume.6 No. 2 p.213 ~ p.219
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Efficacy of the Epidural Buprenorphine for Postoperative Pain Control after Upper Abdominal Surgery
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신감진
최훈/한영진/김동찬/송희선
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Abstract
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The use of buprenorphine by epidural route in the prevention of postoperative pain has been controversial. High lipid solubility of buprenorphine causd the same parenteral/epidural analgesic dose ratio, and the analgesic effect of epidural
buprenorphine
possibly due to systemic absorption, which revealed no advantages of epidural administration against parenteral injection. On the contrary, epidural buprenorphine had longer duration of action and fewer side effects than parenteral buprenorphine,
which
advocated the epidural use of buprenorphine. We studied the efficacy of epidural buprenorphine by comparing epidural buprenorphine with epidural morphine in terms of latency and the duration of analgesic action, and the incidence of side effects.
0.15
mg and 0.3 mg of epidural buprenorphine had shorter latency than 2 mg of morphine. 0.3 mg of buprenorphine had longer duration of action than 4 mg of morphine. The incidence of nausea and vomiting were slightely higher in buprenorphine group than
in
morphine group. Voiding difficulty and pruritus were little in buprenorphine group, while the incidence of somnolence was markedly higher inbuprenorphine group. Form our results we conclude that epidural buprenorphine may be useful in the
treatment
of
postoperative pain, and but recognize both advantages and disadvantages as compared epidural morphine.
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